GABAergic compensation in connexin36 knock-out mice evident during low-magnesium seizure-like event activity
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چکیده
منابع مشابه
GABAergic compensation in connexin36 knock-out mice evident during low-magnesium seizure-like event activity.
Gap junctions within the cerebral cortex may facilitate cortical seizure formation by their ability to synchronize electrical activity. To investigate this, one option is to compare wild-type (WT) animals with those lacking the gene for connexin36 (Cx36 KO); the protein that forms neuronal gap junctions between cortical inhibitory cells. However, genetically modified knock-out animals may exhib...
متن کاملConnexin36 Gap Junction Blockade Is Ineffective at Reducing Seizure-Like Event Activity in Neocortical Mouse Slices
Despite much research, there remains controversy over the role of gap junctions in seizure processes. Many studies report anticonvulsant effects of gap junction blockade, but contradictory results have also been reported. The aim of this study was to clarify the role of connexin36 (Cx36) gap junctions in neocortical seizures. We used the mouse neocortical slice preparation to investigate the ef...
متن کاملComparable GABAergic mechanisms of hippocampal seizure-like activity in post-tetanic and low-Mg conditions
It is known that GABA is a major inhibitory neurotransmitter in mature mammalian brains, but the effect of this substance is sometimes converted into depolarizing or even excitatory when the postsynaptic Cl concentration becomes high. Recently we have shown that seizure-like afterdischarge induced by tetanic stimulation in normal extracellular fluid (post-tetanic afterdischarge) is mediated thr...
متن کاملConnexin36 knockout mice display increased sensitivity to pentylenetetrazol-induced seizure-like behaviors.
OBJECTIVE Large-scale synchronous firing of neurons during seizures is modulated by electrotonic coupling between neurons via gap junctions. To explore roles for connexin36 (Cx36) gap junctions in seizures, we examined the seizure threshold of connexin36 knockout (Cx36KO) mice using a pentylenetetrazol (PTZ) model. METHODS Mice (2-3months old) with Cx36 wildtype (WT) or Cx36KO genotype were t...
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Narcolepsy is a human sleep disorder resulting from the loss of neurons containing the neuropeptide orexin, also known as hypocretin. Cataplexy, which is a sudden loss of muscle tone during waking, is an important diagnostic symptom of narcolepsy. In humans and canines with narcolepsy, cataplexy is considered to be a separate and distinct behavioral state. However, in the mouse model of the dis...
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ژورنال
عنوان ژورنال: Brain Research
سال: 2010
ISSN: 0006-8993
DOI: 10.1016/j.brainres.2010.09.002